Cumulative exposure to higher intensities of oxygen exposure was associated with an increased risk of death in critically ill patients with mechanical ventilation, according to a study published in Crit_Care.
). Based on prior knowledge, baseline variables were purposefully selected to be used in the PAMMs as time-fixed confounders and included age, gender, admission type, weight, and Elixhauser comorbidity score.
]. CMA separates the total effect of exposure into direct and indirect effects. The indirect impact on the outcome is mediated via a mediator. Our study used time-varying high FiOSeveral subgroup analyses were performed according to exposure window , admission type, gender, and initial diagnosis. Since patients could liberate from mechanical ventilation during the follow-up period, we duplicated the analysis after changing the follow-up period.
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