To what extent did the COVID-19 booster strategy prevent infections and hospitalizations in US adults? medrxivpreprint HarvardChanSPH COVID19 coronavirus covid vaccine vaccination booster
By Pooja Toshniwal PahariaJul 29 2022Reviewed by Danielle Ellis, B.Sc. In a recent study posted to the medRxiv* preprint server, researchers estimated the impact of different coronavirus disease 2019 messenger ribonucleic acid booster vaccinations in the United States during fall 2022.
The participants were boosted with the mRNA-1273 monovalent vaccine from September 2022, the mRNA-1273.214 bivalent vaccine from September 2022 onwards, or the mRNA-1273.222 bivalent vaccine from November 2022. In addition, sensitivity analyses were performed based on SARS-CoV-2 transmissibility, mRNA vaccination coverage, masking, Paxlovid treatment, and antibody waning against SARS-CoV-2 over time.
It was assumed that the prime vaccinations for the study participants were combinations of the BNT162b2 and AD26.COV2.S and mRNA-1273 vaccines and that all participants received prime vaccinations and initial booster vaccinations before 31 May 2022, and the second booster vaccinations before 15 June 2022.
The model predicted that by September 2022, individuals who received only prime vaccinations or the first booster would elicit no vaccine-induced immunity, while VE for the second booster was 1 year, the mRNA-1273, mRNA-1273.214, and mRNA-1273.222 boosters were estimated to decrease SARS-CoV-2 infections by 36%, 47%, and 45%, respectively, in comparison to booster vaccinations in the fall period.
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