Scientists developing early Alzheimer'sdisease detection sensor sfu NatureComms
. An asymmetric contact geometry also offers a simple fabrication process requiring only one metallization layer and no doping process.
Here, we report the detection of the pro-inflammatory cytokine TNF-α, at concentrations as low as 10 fM using an asymmetric geometry diode, with a wide dynamic range of detection from concentrations of 10 fM to 1 nM. We employ a well-known silane functionalization process and aptamer cytokine interaction to demonstrate the detection of cytokines using this device architecture.
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Integration of Hi-C with short and long-read genome sequencing reveals the structure of germline rearranged genomes - Nature CommunicationsHere the authors characterize structural variations (SVs) in a cohort of individuals with complex genomic rearrangements, identifying breakpoints by employing short- and long-read genome sequencing and investigate their impact on gene expression and the three-dimensional chromatin architecture. They find breakpoints are enriched in inactive regions and can result in chromatin domain fusions.
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Cross-sectional associations of different types of nature exposure with psychotropic, antihypertensive and asthma medicationBackground Exposure to natural environments is thought to be beneficial for human health, but the evidence is inconsistent. Objective To examine whether exposure to green and blue spaces in urban environments is associated with mental and physical health in Finland. Methods The Helsinki Capital Region Environmental Health Survey was conducted in 2015−2016 in Helsinki, Espoo and Vantaa in Finland (n=7321). Cross-sectional associations of the amounts of residential green and blue spaces within 1 km radius around the respondent’s home (based on the Urban Atlas 2012), green and blue views from home and green space visits with self-reported use of psychotropic (anxiolytics, hypnotics and antidepressants), antihypertensive and asthma medication were examined using logistic regression models. Indicators of health behaviour, traffic-related outdoor air pollution and noise and socioeconomic status (SES) were used as covariates, the last of these also as a potential effect modifier. Results Amounts of residential green and blue spaces or green and blue views from home were not associated with medications. However, the frequency of green space visits was associated with lower odds of using psychotropic medication (OR=0.67, 95% CI 0.55 to 0.82 for 3–4 times/week; 0.78, 0.63 to 0.96 for ≥5 times/week) and antihypertensive (0.64, 0.52 to 0.78; 0.59, 0.48 to 0.74, respectively) and asthma (0.74, 0.58 to 0.94; 0.76, 0.59 to 0.99, respectively) medication use. The observed associations were attenuated by body mass index, but no consistent interactions with SES indicators were observed. Conclusions Frequent green space visits, but not the amounts of residential green or blue spaces, or green and blue views from home, were associated with less frequent use of psychotropic, antihypertensive and asthma medication in urban environments. No data available based on General Data Protection Regulation.
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Preston Police thank Mother Nature as snowy footprints help ensnare suspectsFootprints in icy snow in Preston Pic: Tony Worrall The cold weather has done Preston Police a favour with a set of snowy footprints helping officers link t
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Multimodal single-cell and whole-genome sequencing of small, frozen clinical specimens - Nature GeneticsHigh-quality multimodal single-cell, bulk and spatial genomics data are prepared from low-input, frozen needle biopsy specimens collected during routine clinical procedures.
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Footprints in snow help Preston police identify suspectsOfficers investigating an offence thank 'Mother Nature for her assistance' in catching two suspects.
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What does the future of clinical trials and evidence-based medicine look like?In a recent perspective published in Nature Medicine, the researcher shared his vision and future perspectives for the domains of clinical research and evidence-based therapeutics.
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