The dynamics and molecular mechanisms of T cell therapies are probed in cancer organoids
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Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Emission spectra of the indicated fluorescent real-time cell dyes separately imaged by multispectral imaging with the lambda mode using the indicated lasers. Overview of fluorescent real-time cell dyes for labelling the indicated cell types. Schematic representation of the co-culture setup.
Heatmap showing normalized gene expression for the indicated PDOs harvested at two different time points in culture . GO terms ‘extracellular matrix and ECM- associated proteins’ , ‘cytokines signaling in immune system’ and ‘interferon signaling’ are presented, which were identified in the gene ontology enrichment analysis of differentially expressed genes between the six highest versus six lowest TEG-sensitive organoid cultures from Fig.
. Error rate of the training data per cluster and overall for all trees and correlation plot between ground truth cluster classification and predicted cluster classification . Color represents ground truth cluster. Quantification of head and neck cancer PDO or diffuse midline glioma PDO targeting using a CellTiter-Glo® viability assay upon overnight co- culture with TEGs in the presence of pamidronate. Data corrected for control LM1 T cell responses. .
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