Understanding How Nanoparticle Elasticity Affects Physiological Fate: nanoparticles bionanotechnology nanoparticle nano nanoscience NatureComms
By Dr. Priyom Bose, Ph.D.Aug 3 2022Reviewed by Megan Craig, M.Sc. A recent study published in Nature Communications revealed that nanoparticle elasticity is altered by modulating protein corona, which in turn affects nanoparticles’ systemic circulation lifetime.
Recent studies revealed that nanoparticles’ elasticity significantly influences nanoparticle physiological performance. For instance, it considerably affects nanoparticle biodistribution, systemic circulation lifetime, cellular uptake efficiency, and mode of cell internalization. Scientists stated that although it is clear that nanoparticle elasticity is an important physiological parameter that influences various biological processes, the underlying mechanism is not clear.
It is important to restrict the protein corona formation because it affects the functionalities of nanoparticles—for instance, the presence of protein corona on nanoparticles masks their targeting ability to specific ligands. Several studies have indicated that physiochemical properties of nanoparticles, such as their size, hydrophobicity, shape, surface change, etc., affect protein corona formation.
Compared to other plasma proteins, ApoA1 was found to be abundantly present, which positively correlated with nanoparticles’ systemic circulation lifetime in mice. Scientists revealed that ApoA1 could selectively bind to nanoparticles of intermediate elasticity compared to softer or stiff nanoparticles.
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