Understanding the biological effects of SARS-CoV-2 persistence in children LancetMicrobe longcovid COVID19 SARSCoV2 childhealth childrenshealth
By Shanet Susan AlexJun 29 2023Reviewed by Lily Ramsey, LLM In a study published in The Lancet Microbe, researchers analyzed the most recent knowledge about severe acute respiratory syndrome coronavirus 2 antigen or ribonucleic acid persistence in SARS-CoV-2-infected children.
Nonetheless, the precise pathogenesis is yet unknown. Presently, the focus is on the persistence of the virus or its components in the human body following initial infection. The team also analyzed why these findings may serve as a basis for future therapeutic and diagnostic studies on SARS-CoV-2 infection. They also included the personal experience of a doctor and patient in the study.
These events have been observed in patients with the SARS-CoV-2 pre-Omicron variant infections. Hence, these results might not apply to individuals with the Omicron variant infection. In three studies, pediatric patients with COVID-19-linked pneumonia showed RT-PCR-confirmed viral infection of respiratory tissues.
Two included publications examining the presence of SARS-CoV-2 RNA in tissues of stillborn babies who died following maternal COVID-19 during pregnancy detected viral RNA in their organs. The most frequent anatomopathological observations were associated with intrauterine hypoxia, asphyxia, hemosiderosis, and hepatocellular damage.
Moreover, evidence suggests that long-term SARS-CoV-2 antigenemia can result in a hyperinflammatory presentation in multisystem inflammatory syndrome and long COVID among pediatric populations. Although SARS-CoV-2 vaccination may not be an immunomodulatory therapy, a 2023 systematic review discovered that it has therapeutic impacts on long COVID through rebalancing and boosting the immune system. Nonetheless, no research has been published examining the same effects in pediatric populations.
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