Unlocking HIV cure: Study highlights allogeneic immunity as key mechanism in eradicating latent virus reservoirs AlloHSCT HIVCure StemCellTransplantation Alloimmunity ViralReservoir HIVResearch Immunotherapy HIV ImmunityCP
By Dr. Priyom Bose, Ph.D.Jun 19 2023 The key obstacle against the cure of human and simian immunodeficiency virus infections is the reservoir of proviruses, which are robustly incorporated into the genomes of host CD4+ T cells. As a result, these viruses persist following anti-retroviral therapy and cause virus rebounds upon ART cessation in most cases.
Study: Allogeneic immunity clears latent virus following allogeneic stem cell transplantation in SIV-infected ART-suppressed macaques. Image Credit: BioMedical / Shutterstock Several inherent challenges are associated with HIV studies in clinical settings, such as diverse ART and transplant regimens, low case numbers, limited tissue and blood availability, varied infection history, and reservoir size, and the need for long-term ART interruption to validate cure. Many of these limitations could be overcome by a pre-clinical model of alloHSCT, which would provide greater insights into the immunological processes that eliminate latent HIV.
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