Unlocking the mechanisms of pluripotent cell's fate determination

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Unlocking the mechanisms of pluripotent cell's fate determination
CellEmbryonic Stem CellsGene
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As embryos, all complex organisms are partially made up of pluripotent stem cells, a term for cells that have the capacity to differentiate into any kind of cell: nerve cells, muscle cells, blood cells, skin cells, and the like.

Apr 29 2024Lewis & Clark College As the ultimate biological "shape-shifters," these cells are proving key to regenerative medicine, drug development, genetic research, and related fields.

It shouldn't be easy to derail any of these processes, right? They've been perfecting themselves over the millennia to have the most selectively advantageous system." Torigoe is investigating a small part of these complicated systems. Her work was recently recognized by the National Science Foundation with a three-year Research in Undergraduate Institutions grant.

Related StoriesWhile some scientists learn about the rules of gene expression by studying thousands of genes simultaneously through machine learning, Torigoe's approach is to examine one or two individual genes at a time. Scientists studying enhancers refer to their characteristics as grammar because, according to Torigoe, an enhancer's protein binding sites could be likened to individual words. A series of binding sites are like a sentence built on multiple words that, when strung together, create meaning.

Torigoe says her students sometimes find the complicated nature of investigating enhancer grammar frustrating because there is usually not a simple answer or explanation to their questions.

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Cell Embryonic Stem Cells Gene Gene Expression Genes Genetic Medicine Muscle Nerve Pluripotency Protein Research Skin Skin Cells Stem Cells Students Transcription

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