Unraveling the complexity of 'Long-COVID' and its impact on breathing PostCOVID19 LongCOVID Breathlessness Pulmonary Rehabilitation COVIDResearch RespiratoryHealth Breathing LancetRespirMed
By Neha MathurJun 5 2023 In a recent article published in The Lancet, researchers described the heterogeneous nature of long coronavirus disease , focusing on its pulmonary and extrapulmonary sequelae. They reviewed pre-existing respiratory issues [e.g., lung fibrosis, asthma, and chronic obstructive pulmonary disease ] that possibly aggravate pulmonary sequelae of COVID-19 or affect its outcomes.
Multiple previous studies have described worsening of respiratory systems during PASC due to destabilizing of pre-existing symptoms or COVID-19-related effects, independent of the severity of acute illness; however, the exact mechanisms governing these changes remain unclear. About the study To this end, in the present study, researchers extensively searched databases, such as PubMed and CINAHL, using keywords like dysfunctional breathing, post-COVID fibrosis, fibrosis, and rehabilitation, to name a few.
Extrapulmonary and pulmonary sequelae of COVID-19 In this study, researchers discussed the incidence and mechanisms of pulmonary fibrosis, pulmonary emboli, and microvascular thrombi, COPD, reduced exercise tolerance, and frailty after COVID-19.
In post-COVID-19 conditions, cardiopulmonary exercise testing identified dysfunctional breathing or an erratic breathing pattern in the absence of a respiratory limitation or impaired oxygen delivery and reported a lower peak oxygen uptake in individuals with persistent breathlessness compared with those who had a full recovery after COVID-19.
Likewise, mechanistic similarities between COVID-19-related pneumonia and idiopathic pulmonary fibrosis , raise the possibility of a potential global burden of long-term fibrosis arising post-COVID-19.
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