The US has extended its coronavirus vaccine mandate for foreign travelers entering by air. Travelers must show proof of: ✈️💉 At least two Covid-19 vaccine doses ✈️💉 An acceptable single-dose jab such as Johnson & Johnson.
The Biden administration has extended the coronavirus vaccine requirement for foreign travelers at least through April 10 A Centers for Disease Control and Prevention policy around the vaccines was set to expire on January 8. But the policy will now be enforced at least through April 10, according to anThe extension means that all foreigners coming to the US will have to show proof of at least two Covid-19 vaccine doses or an acceptable single-dose jab such as Johnson & Johnson.
It makes the US stand apart from most western nations which have lifted the vaccine requirements after they did not seem to curb infection rates. The UK and most European countries have ditched the ‘vaccine passport’ requirement. The Covid-19 vaccine requirement was set to expire on January 8 before the Biden administration extended it requiring airline passengers traveling from ChinaAmerica issued a policy limiting entry ‘of non-citizens by air travel who are nonimmigrants and who are not fully vaccinated against Covid-19’ in October 2021, according to theHowever, the testing requirement for Chinese travelers by air becomes effective midnight on January 5.
The TSA claims that its latest emergency amendment is designed to protect Americans from the virus and prevent hospitals from getting filled with patients. ‘Together with the Presidential Proclamation and the CDC Order, these policies are intended to limit the risk that Covid-19, including variants of the virus that causes Covid-19, is introduced, transmitted, and spread into and throughout the United States,’ states the TSA document, ‘Potentially overwhelming United States healthcare and public health resources, endangering the health and safety of the American people, and threatening the security of our civil aviation system.
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Genome-Wide Pleiotropy Study Identifies Association of PDGFB with Age-Related Macular Degeneration and COVID-19 Infection OutcomesAge-related macular degeneration (AMD) has been implicated as a risk factor for severe consequences from COVID-19. We evaluated the genetic architecture shared between AMD and COVID-19 (critical illness, hospitalization, and infections) using analyses of genetic correlations and pleiotropy (i.e., cross-phenotype meta-analysis) of AMD (n=33,976) and COVID-19 (n ≥ 1,388,342) and subsequent analyses including expression quantitative trait locus (eQTL), differential gene expression, and Mendelian randomization (MR). We observed a significant genetic correlation between AMD and COVID-19 infection (rG=0.10, p=0.02) and identified novel genome-wide significant associations near PDGFB (best SNP: rs130651; p=2.4 × 10−8) in the pleiotropy analysis of the two diseases. The disease-risk allele of rs130651 was significantly associated with increased gene expression levels of PDGFB in multiple tissues (best eQTL p=1.8 × 10−11 in whole blood) and immune cells (best eQTL p=7.1 × 10−20 in T-cells). PDGFB expression was observed to be higher in AMD cases than AMD controls {fold change (FC)=1.02; p=0.067}, as well as in the peak COVID-19 symptom stage (11–20 days after the symptom onset) compared to early/progressive stage (0–10 days) among COVID-19 patients over age 40 (FC=2.17; p=0.03) and age 50 (FC=2.15; p=0.04). Our MR analysis found that the liability of AMD risk derived from complement system dysfunction {OR (95% CI); hospitalization=1.02 (1.01–1.03), infection=1.02 (1.01–1.03) and increased levels of serum cytokine PDGF-BB {β (95% CI); critical illness=0.07 (0.02–0.11)} are significantly associated with COVID-19 outcomes. Our study demonstrated that the liability of AMD is associated with an increased risk of COVID-19, and PDGFB may be responsible for the severe COVID-19 outcomes among AMD patients.
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