The two-time winner, handed a wild card at the age of 43, was beaten 6-1 6-1 in the first round by Belgian Greet Minnen.
“I don’t think I played badly, it was just one of those days where I was unlucky.
Greet Minnen shakes hands with Venus Williams after winning their match during the first round of the US Open Wimbledon runner-up Ons Jabeur had to overcome breathing difficulties to battle past Columbia’s Camila Osorio.France’s Caroline Garcia, seeded seven, suffered a shock exit, 6-4 6-1, to world number 114 Wang Yafan of China.
Canadian Laylah Fernandez, the runner-up to Emma Raducanu two years ago, lost in three sets to Ekaterina Alexandrova.
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