How synapticvesicles accumulate glutamate NatureComms
-glutamate exchange, but only slightly affects proton activation, proton coupling and proton activation are likely to involve distinct protonation processes.-anion exchangers that exploit a variable transport stoichiometry for transport selectivity: only glutamate transport is tightly coupled to Hpermeates through the VGLUTs independently of Hefflux during glutamate accumulation and, thus, osmotically neutral glutamate accumulation.
. HEK293T and Flp-In T-Rex 293 cultures were maintained in humidified incubators at 37 °C and 95% air/5% COTo express VGLUT1 as an eGFP fusion protein, we inserted the coding region of eGFP into pcDNA3.1-rVGLUT1 at the 3ʹ end of the transporter coding region. Using a method similar to Eriksen et al.
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