Vitamin D can reduce severity and spread of COVID-19 Coronavirus Disease COVID Mortality Pandemic SARSCoV2 VitaminD VitaminD3 SciReports thisisUIC UChicago FisherNews UMich JohnsHopkinsSPH
Vitamin D deficiency has long been linked to impaired immunological function, which can result in viral infection. In addition, multiple studies have demonstrated that vitamin D deficiency is related to an increased risk of severe acute respiratory syndrome coronavirus 2 infection. However, it is unclear whether Vitamin D therapy can lessen the likelihood of COVID-19 infection.
About the study In the present study, researchers performed a large-scale pharmacoepidemiologic investigation to determine the relationship between vitamin D2 and D3 supplementation and the risk of COVID-19 infection-related mortality within 30 days. Supplementation with vitamin D2 or D3 was the primary exposure prior to and after the pandemic started on 1 March 2020. The reference group consisted of patients who did not receive vitamin D2 or D3 supplementation. l vitamin D2 and D3 products and dosages were incorporated in the Corporate Data Warehouse electronic health records, such as multivitamins and combination medications containing vitamin D3.
Results When potential confounding variables were matched, the groups receiving vitamin D3 supplementation and control participants were comparable. A more significant proportion of Black patients were supplemented with vitamin D2 compared to vitamin D3. In general, vitamin D3 recipients experienced more comorbid illnesses than D2 recipients. The vitamin D3 cohort displayed COVID-19 infection rates of 2.66% and 3.30% for the treated and the controls, respectively.
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