What is the prevalence of contraindications to Paxlovid among hospitalized COVID-19 patients? univ_paris_cite COVID19 SARSCoV2 Paxlovid Coronavirus
By Neha MathurNov 17 2022Reviewed by Aimee Molineux In a recent study published in JAMA Network Open, researchers examined the prevalence of contraindications to nirmatrelvir-ritonavir in hospitalized coronavirus disease 2019 patients.
However, in certain circumstances, Paxlovid should be avoided due to the effects of ritonavir. In some patients, ritonavir elevates the concentrations of drugs more dependent on cytochrome P450, family 3, and subfamily A metabolism, for instance, in patients with severe kidney and liver impairments.
The primary study outcome was the number of patients with contraindications to nirmatrelvir-ritonavir. Next, the researchers determined the proportion of individuals who died within 28 days of hospitalization. These patients might have needed another therapy in the ambulatory setting. Study findings Only 62,525 COVID-19 inpatients met the study criteria, of which 9136 had a medical contraindication to nirmatrelvir-ritonavir. The study population comprised 31,561 women [50.5%], and the mean age of the participants was 52.8 years. The researchers noted that medical contraindication rates to nirmatrelvir-ritonavir were higher in men than women .
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