How your genes could put you at risk for Alzheimer’s There are thousands of genetic variants that can raise your risk of the disease, explains StuartJRitchie - and there’s evidence that people with more of these genetic risks will develop it earlier
Phillips is 62, so would normally be classed as an “early-onset” Alzheimer’s patient – the majority of scientists working in this area consider an Alzheimer’s diagnosis before 65 to be in this category . Early-onset Alzheimer’s is rare, making up only about 5 per cent of cases.
“Genetic risk” can mean several different things. For very many health conditions, particularly those that affect the brain , there aren’t just a handful of DNA variations that affect your risk – there are thousands. Each little genetic variation adds a tiny bit to the probability that you might develop the disease in future, and even if you have a lot of them, there’s still a decent chance you’ll never get it.
Alzheimer’s is somewhere in between these two poles. There are thousands of genetic variants that canby just a small amount, depending on which version – which “allele” – of each of them that you have. People with more of the risk-raising alleles are those who are more likely to get the disease.
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