Wireless smart bandage provides new insights on healing chronic wounds

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Wireless smart bandage provides new insights on healing chronic wounds
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Wireless smartbandage provides new insights on healing chronicwounds NatureBiotech

The electronic layer, including a microcontroller unit , radio antenna, memory, electrical stimulator, biosensors, and other components, is just 100 microns thick—about the thickness of a single coat of latex paint.

"In sealing the wound, the smart bandage protects as it heals," says Yuanwen Jiang, co-first author of the study and a post-doctoral scholar in the lab of Zhenan Bao, the K.K. Lee Professor in Chemical Engineering in the Stanford School of Engineering."But it is not a passive tool. It is an active healing device that could transform the standard of care in the treatment of chronic wounds.

The smart bandage's biosensing capabilities monitor biophysical changes in the local environment, providing a real-time, rapid, robust, and extremely accurate way to measure wound condition. Technically speaking, the smart bandage senses conductivity and temperature changes in the skin as the wound heals—electrical impedance increases as wounds heal and local temperatures decline as inflammation subsides.

Likewise, electrical stimulation increased the amount of white blood cell populations, namely monocytes and macrophages, through the recruitment of greater amounts of M2 anti-inflammatory macrophages, which have been previously reported as pro-regenerative and playing a key role in the extracellular matrix formation that is required during the proliferative phases of wound healing.

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