itemprop=description content=The overlap in clinical and magnetic resonance imaging (MRI) findings between Alzheimer's disease and glaucoma.
By Pooja Toshniwal PahariaOct 9 2023Reviewed by Lily Ramsey, LLM In a recent review published in the International Journal of Molecular Sciences, researchers described the overlap in clinical and magnetic resonance imaging findings between Alzheimer's disease and glaucoma.
Clinical and MRI biomarkers among individuals with glaucoma Glaucoma is a multifactorial degenerative optic neuropathy defined by the loss of retinal ganglion cells, resulting in permanent vision field impairment. It is thought to be a neurodegenerative illness that begins in the brain but appears as an eye condition, lending credence to the existence of the brain-eye axis.
Primary open-angle glaucoma patients had a larger clustering coefficient in the calcarine gyrus, lingual gyrus, lateral occipital gyrus, and paracentral lobe, and global strength, global efficiency, and global clustering coefficient in glaucoma patients. Neuronal loss in the medial temporal and parietal lobes causes cortical atrophy in AD, which extends to limbic structures in the gray matter and, eventually, to the frontal cortex. Atrophy commences in the medial temporal lobe region involving the hippocampus and entorhinal cortex.
Reduced fractional anisotropy and increased tissue diffusivity are documented in the temporal and frontal lobes, corpus callosum, posterior cingulate, uncinate, and superior longitudinal bundles of individuals with Alzheimer's disease compared to healthy individuals.
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