Analytical and clinical evaluation of antigen-based rapid diagnostic tests against the most encountered SARS-CoV-2 variants medrxivpreprint LSTMnews OfficialUoM diagnostics diagnosis SARSCoV2 COVID19 coronavirus covid
By Dr. Priyom Bose, Ph.D.Aug 2 2023Reviewed by Sophia Coveney A recent study posted on the medRxiv* preprint server has assessed the sensitivity of antigen-based rapid diagnostic tests .
Ag-RDTs can be performed at home by lay individuals to detect an infection. These diagnostic tests are inexpensive, do not require skilled personnel, and provide results rapidly. The Omicron variant contains the highest number of mutations throughout the genome that include spike , envelope , membrane , and nucleocapsid protein regions.
All clinical samples were obtained from the ‘Facilitating Accelerated Clinical Evaluation of Novel Diagnostic Tests for COVID-19’ study. Nasopharyngeal swabs were collected from symptomatic participants who visited the COVID-19 test center in Liverpool John Lennon Airport, UK, between January 2021 and March 2022.
Clinical evaluations were performed on five out of thirty-four Ag-RDT brands. Compared to all tested Ag-RDTs brands, Onsite exhibited the best overall sensitivity, while Hotgen consistently performed poorly.
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