Association of BCG Vaccine Treatment With Death and Dementia in Patients With Bladder Cancer

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Association of BCG Vaccine Treatment With Death and Dementia in Patients With Bladder Cancer
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Early data suggest the Bacillus Calmette-Guérin vaccine could have a protective effect against Alzheimer's jamanetworkopen

have noted an intriguing and consistent association between the use of BCG vaccine for bladder cancer and a decreased incidence of ADRD. Limitations to these studies include sample size, cohort insularity, and/or analytical methods.

. The TURBT pathology reports were categorized as benign or malignant based on a combination of NLP using regular expressions and manual reviews. For reports of malignancy, cancer stage was determined by NLP with REGEX, categorizing patients as having NMIBC or MIBC according to standard TNM tumor classification. Natural language processing also was used to identify pathology reports suggesting prior cystectomy, locally invasive, or metastatic bladder cancer.

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