Cells dancing harmonic duets could enable personalized cancer therapies NatureMaterials
or cells has been a major target in the field of acoustic manipulation for many years," said Tony Jun Huang, the William Bevan Distinguished Professor of Mechanical Engineering and Materials Science at Duke."Our HANDS platform is the first method of separating paired objects, which provides a way into cell-cell interaction studies that are needed extensively in biophysics studies and drug discovery.
The new device works by placing sound-creating transducers on each side of a small square chamber filled with liquid. These four transducers work in step with those directly across from them, forming two pairs. One creates patterns in the chamber horizontally and the other vertically. The interaction of these two complex, quickly changing sound wave patterns creates dynamic abilities never before demonstrated within the field.
In the paper, Yang demonstrates several novel abilities of the harmonic duet acoustic tweezers. In one experiment, he shows that the HANDS platform can flatten and pattern a 3D cluster of 24 particles into a crystalline structure. It can spin these flat formations like a plate on a fingertip.
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