Does the immunization order of vaccine types influence the efficacy of heterologous prime-boost vaccination, especially mRNA and protein-based vaccines? researchsquare immunization vaccine booster vaccination mRNA
By Suchandrima BhowmikJan 6 2023Reviewed by Danielle Ellis, B.Sc. There has been an increase in the development of coronavirus disease 2019 vaccines in several countries due to the rapid spread of severe acute respiratory syndrome coronavirus 2 .
Antibodies eBook Compilation of the top interviews, articles, and news in the last year. Download a free copy Recently, a traditional protein subunit type vaccine, Novavax has been approved by the FDA for emergency use. The availability of these vaccines has led to the administration of different types of vaccines to immunize people against a single virus.
A new study available on as a preprint on Research Square* and under review at npj Vaccines aimed to analyze whether the order of immunization of vaccine types impacted the efficacy of a heterologous prime-boost vaccination strategy. Study findings The results indicated that priming with led to high levels of IgG2a, whereas priming with protein-HA led to an IgG1-biased response. Homologous mRNA-HA-immunization and heterologous mRNA-HA/protein-HA-immunization were observed to lead to balanced IgG1/IgG2a responses.
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