Drugs with antiviral activity against monkeypox virus Drugs tecovirimat brincidofovir cidofovir Monkeypox Virus Virology CIDJournal OUHealth IDSAInfo SIDPharm
Human monkeypox is a zoonosis caused by MPXV, a double-stranded DNA virus member of the Orthopoxvirus genus. The first case of hMPX was reported in 1970 in the Democratic Republic of Congo. Multiple outbreaks have occurred in West and Central Africa, with occasional outbreaks in North America and Europe.
Study: Antivirals with Activity Against Monkeypox: A Clinically Oriented Review. Image Credit: NIAID CDV has been used in humans for treating infections with poxviruses. Case reports revealed the use of intravenous CDV in a multipronged approach for ocular cowpox. Its combined use with ST-246 has been documented in a patient with eczema vaccinatum. Topical CDV has been used in children and adults for treating molluscum contagiosum. Typically, lesions become acutely inflamed following CDV application but resolve dramatically.
The prairie dog model for MPXV has a similar infection course as in humans. In these dogs, BCV improved survival when administered shortly after MPXV exposure, indicating that early treatment is essential for efficacy. ST-246 is available in oral and intravenous formulations. It has superior absorption when administered in the fed state. It has been effective against MPXV in macaques and prairie dogs. Administering ST-246 within 72 hours of exposure to poxvirus was efficacious in reducing lesion severity and preventing mortality in different animal models.
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