Study shows FDA-approved TB regimen may not work against the deadliest form of TB due to multidrug-resistant strains NatureComms
and represent a single time point, and not time-concentration curves as measured by PET. This difference in measurement could explain why the brain/plasma ratios were found to be higher by mass spectrometry compared to PET-derived AUC ratios. Moreover, since, and brain uptake reaches C18
F-pretomanid to reach the brain. While rabbit studies utilized both males and females, only female mice were used, and future studies with both males and females would be required to investigate how gender may affect pretomanid PK. Finally, while the reduced penetration of linezolid and bedaquiline into the brain parenchyma are a likely cause of the reduced efficacy of the BPaL regimen compared to standard TB therapy , other factors may be considered, and further research is needed.
Here we show the value added by imaging technologies for the characterization of novel drugs and treatment optimization.
. Importantly, our studies demonstrate that pretomanid has excellent penetration into the CNS, confirmed in first-in-humanF-pretomanid studies, suggesting that novel pretomanid-based regimens in combination with other antibiotics active against MDR strains and with excellent brain penetration should be considered for the treatment of MDR-TB meningitis.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Molecular imaging of pulmonary inflammation in electronic and combustible cigarette users: a pilot studyElectronic cigarette (EC) use has increased dramatically, particularly among adolescents and young adults, which, like cigarette use, can cause pulmonary inflammation and increase the risk of lung disease. Methods: This preliminary study used positron emission tomography with 18F-6-(1/2)(2-fluoro-propyl)-4-methylpyridin-2-amine (18F-NOS) to quantify inducible nitric oxide synthase (iNOS) expression to characterize oxidative stress and inflammation in the lungs in vivo in three age- and sex-matched groups: (1) 5 EC users, (2) 5 cigarette smokers, and (3) 5 never smoke/vape controls. Results: EC users showed greater 18F-NOS non-displaceable binding potential (BPND) than cigarette smokers ( P=0.03) and never smoke/vape controls ( P=0.01); whereas BPND in cigarette smokers did not differ from controls (p| 0.1). 18F-NOS lung tissue delivery and iNOS distribution volume did not significantly differ between groups. Although there were no group differences in peripheral inflammatory biomarker concentrations, 18F-NOS BPND correlated with the pro-inflammatory cytokine tumor necrosis factor-α concentrations (rs=0.87, P=0.05) in EC users. Additionally, when EC users and cigarette smokers were pooled together, vaping episodes/cigarettes per day correlated with interleukin-6 levels (rs=0.86, P=0.006). Conclusion: This is the first PET imaging study to compare lung inflammation between EC and cigarette users in vivo. We found preliminary evidence EC users had greater pulmonary inflammation than cigarette smokers and never smoke/vape controls, with a positive association between pulmonary and peripheral measures of inflammation.
Read more »
Pet dog headbutts Leeds veterinary nurse in the chest and saves her lifeAngie Shaw was left with a lump from the incident and went to see her GP
Read more »
Drama as llama Grant goes missing leaving family 'distraught'Grant must be missing his family and his favourite food -chocolate ice cream. Have you seen Grant?
Read more »
Furious neighbour demands woman change her cat's 'offensive' nameThe pet owner says she came under fire after naming her feline 'Lucifer'.
Read more »
I was ghosted after sending a crush a dating questionnaire, but I'd send one againIt could have helped me weed out several dating app duds, like the carpenter with the pet snake or the videographer who had a penchant for ketamine
Read more »
Dog owners warned as palm oil lumps wash up in CumbriaThe coastguard warns dog owners who suspect their pet has eaten palm oil to alert their vet.
Read more »