A seminal 2006 study of Alzheimer's disease might contain fabricated results, an investigation from Science magazine found.
, launched interest in a specific protein called Aβ*56 as a promising target for early intervention in Alzheimer's disease.a phenomenon that is widely believed to be linked to the development of Alzheimer's disease. Several different types of these proteins are potential targets for drugs treating Alzheimer's.
Whistleblower Matthew Schrag, a neuroscientist at Vanderbilt University, first flagged his concerns about the images to the NIH on January 2022.asked two image analysis experts to review Lesné's published work. They echoed Shrag's concerns. They identified a total of 20"suspect papers" authored by Lesné, 10 of which had to do with Aβ*56, perThe publication stopped short of alleging misconduct or fraud, stating that the original images would have to be investigated for manipulation to be confirmed.
The most"obvious" effect of this alleged manipulation would be"wasted NIH funding and wasted thinking in the field," Nobel laureate and Stanford University neuroscientist Thomas Südhof told
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