Gene engineered cell therapy developed to target brain metastatic melanomas brighamwomens sciencetm
to deliver the virus amplifies the amount of virus that can be released and ensures that the virus will not be degraded by circulating antibodies before it is released on the cancer cells.also destroys the very cells that release it, making it an unsustainable therapeutic option on its own.
The authors emphasize that this approach can be used in other cancers with brain metastasis, such as lung andNotably, the authors were able to design a preclinical mouse model that faithfully represents a human model of melanoma with leptomeningeal metastasis, which they used to test their therapy.
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