Impaired glucose tolerance and cardiovascular risk factors associated with fertility problems medrxivpreprint GlucoseTolerance CardiovascularRisk Fertility
By Dr. Priyom Bose, Ph.D.Jan 31 2023Reviewed by Benedette Cuffari, M.Sc. In both men and women, impaired glucose tolerance and cardiovascular risk factors have been implicated in fertility problems. Mendelian randomization is an important method that is based on genetic variables to measure potential causal effects without being affected by confounding factors.
About the study The researchers of the current study obtained data from the Norwegian Mother Father and Child Cohort Study , which is a population-based pregnancy cohort designed by the Norwegian Institute of Public Health. This Norway-based cohort comprised pregnant women, who were at around 18 gestational weeks, as well as their partners, between 1999-2008.
In this study, about 12% of the couples reported infertility. These couples were more likely to be obese, of older age, have lower education status, and be smokers. The prevalence of hyperinsulinemia, which is a biomarker for insulin resistance and glucose intolerance, has been previously associated with polycystic ovary syndrome , which causes infertility. In addition, hyperinsulinemia is linked with impaired synthesis of sexual hormones in the follicle, including lower levels of progesterone and follicle-stimulating hormone and increased levels of androgens, along with follicular dysplasia.
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