If you have no particularly strong feelings about horses in The Sims 4, join the club. However, plenty of fans have bee…
Now, though, it looks like it's finally time for much-requested horses to shine; EA has announced its latest The Sims 4 development roadmap, promising two"bold kits" for release between June and September, as well as a"rootin' tootin' expansion".
And if the latter phrasing wasn't suggestive enough of horses for you, EA's newly shared tease also features the line"take the reins", superimposed over a craggy vista, indicating some sort of Western-inspired getaway expansion might be on the way.suggesting the new expasion is called Horse Ranch, and includes a new world, horse rearing, new events, plus mini sheep and mini goats.this Thursday, 22nd July, just before 6pm BST.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
The Sims 4 is finally getting the horse expansion players have been demanding for yearsTyler grew up in Silicon Valley during the rise of personal computers, playing games like Zork and Arkanoid on the early PCs his parents brought home. He was later captivated by Myst, SimCity, Civilization, Command & Conquer, Bushido Blade (yeah, he had Bleem!), and all the shooters they call 'boomer shooters' now. In 2006, Tyler wrote his first professional review of a videogame: Super Dragon Ball Z for the PS2. He thought it was OK. In 2011, he joined PC Gamer, and today he's focused on the site's news coverage. His hobbies include amateur boxing and adding to his 1,200-plus hours in Rocket League.
Read more »
The Sims 4 horses expansion all but confirmed following leaks'A rootin' tootin' expansion.'
Read more »
Glasgow reporter 'badly beaten' after being held in Turkish detention centreSermad Al-Khafaji, 43, and fellow Scot, Alexandra Foreman, 34, tavelled to Turkey last month to film asylum seekers making their way into Bulgaria, however, they were detained.
Read more »
A week with San Marino - the worst international football team in the worldSan Marino, a tiny European republic of less than 34,000 people, is winless in 129 straight matches. They're the worst national team in the world. But for their people, pride endures.
Read more »
β-catenin drives butyrophilin-like molecule loss and γδ T-cell exclusion in colon cancerAbstract. Intraepithelial lymphocytes (IELs) expressing γδ T-cell receptors (γδTCRs) play key roles in elimination of colon cancer. However, the precise mechanisms by which progressing cancer cells evade immunosurveillance by these innate T cells are unknown. Here, we investigated how loss of the Apc tumor suppressor in gut tissue could enable nascent cancer cells to escape immunosurveillance by cytotoxic γδIELs. In contrast with healthy intestinal or colonic tissue, we found that γδIELs were largely absent from the microenvironment of both mouse and human tumors, and that butyrophilin-like (BTNL) molecules, which can critically regulate γδIEL through direct γδTCR interactions, were also downregulated in tumors. We then demonstrated that β-catenin activation through loss of Apc rapidly suppressed expression of the mRNA encoding the HNF4A and HNF4G transcription factors, preventing their binding to promoter regions of Btnl genes. Re-expression of BTNL1 and BTNL6 in cancer cells increased γδIEL survival and activation in co-culture assays but failed to augment their cancer-killing ability in vitro or their recruitment to orthotopic tumors. However, inhibition of β-catenin signaling via genetic deletion of Bcl9/Bcl9l in either Apc-deficient or mutant β-catenin mouse models restored Hnf4a, Hnf4g, and Btnl gene expression and γδ T-cell infiltration into tumors. These observations highlight an immune-evasion mechanism specific to WNT-driven colon cancer cells that disrupts γδIEL immunosurveillance and furthers cancer progression.
Read more »
The ‘silent’ cervical cancer symptom you can feel in your back & 8 other signsOVER two women die of cervical cancer each day in England. However, the aggressive disease can generally be cured if caught early. Spot and treat it at the earliest stage – stage 1 – an…
Read more »