A Review published in The Journal of Headache and Pain summarizes the most recent evidence about long COVID headache and suggests approaches to the diagnosis and treatment of this disorder.
The frequency of long COVID headache seems to be similar in patients with severe and non-severe forms of COVID-19 disease. In a meta-analysis which evaluated 35 studies up to May 2021, accounting for 28,348 COVID-19 survivors, the prevalence of post-COVID headache was higher in patients that were managed in an outpatient setting during the acute phase, but not at 30, 60 or 90 days [].
]. Low information are available about differences between headache characteristics in patients following ICU admission for severe Sars-CoV-2 infection or in those cases treated at home, or in patients having longer hospitalization, who were ventilated or not. Trigeminovascular system activation in patients with genetic predisposition to migraine or pre-existing headache
It has been hypothesized that long COVID headache could emerge as a result of the “activation” of a pre-existing headache or in patients with a genetic predisposition to migraine by activating the trigeminovascular system. In the previously mentioned study, some migraine-like features of the headache during the acute phase were associated with long COVID headache.
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