Neuroinflammatory proteins may serve as novel biomarkers to distinguish neurodegenerative diseases, suggests a study published in the Journal of Neuroinflammation.
]. To our knowledge, there has not been any previous reports of IL13 involvement in PSP. Anti-inflammatory proteins have been found to be part of the neuropathologic process in other diseases, such as AD, but they were believed to be part of a protective feedback pathway []. Additional work will be needed to better understand how IL13 might be involved in PSP pathogenesis.
The final two diseases, CBD and AGD, demonstrated much less agreement with their respective clusters. ROC analysis for the top 5 PLS candidates for each disease did not reach significance, and only GMCSF correlated with AGD in a binary logistic regression. Although CBD and AGD had the highest correlation with Cluster 4 and 5, respectively, Fig.demonstrated that there appeared to be moderate correlation with the other diseases as well.
Although gender was controlled for during the PLS and binary logistic regressions, it is important to point out that the CTE group was composed entirely of males which could skew results. This was due to the current lack of females diagnosed with CTE, as many of the donated samples were derived from individuals who played American football, a sport dominated by males. To account for this skew, a sub-analysis with just males was performed.
While this current study is one of the most comprehensive to date looking at dozens of different proteins across 5 different diseases, there are likely many more differences not captured with the multiplex ELISA. More unbiased proteomic techniques like mass spectrometry would be useful to identify the full spectrum of differences present between diseases and identify additional targets.
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Watch for tachycardia - International Journal of ArrhythmiaBackground Wearable devices capable of measuring health metrics are becoming increasingly prevalent. Most work has investigated the potential for these devices in the context of atrial fibrillation, our case highlights the potential of wearable devices across a wider range of arrhythmia. Case presentation A 51-year-old woman was referred to the cardiology clinic for an assessment of symptoms of intermittent exertional shortness of breath and palpitation. The patient was otherwise fit and well, took limited alcohol and no caffeine, and was a never smoker. There was no family history of heart disease. Physical examination in clinic was unremarkable, and a 12-lead electrocardiogram (ECG), seven-day ambulatory ECG, exercise stress ECG, and trans-thoracic echocardiogram were all normal. During a severe episode the patient recorded an ECG using an Apple Watch (Apple Inc, California, USA). This was forwarded to the patient’s cardiologist, who suspected a broad complex tachycardia and organised an urgent follow-up appointment. A further 72-h Holter ECG monitor showed frequent sustained periods of monomorphic ventricular tachycardia, confirming the watch findings. The patient was started on beta blocker therapy with a rapid improvement in symptoms. Conclusions Current smartwatch technology can reliably identify irregular rhythms and can distinguish atrial fibrillation from sinus rhythm, with emerging evidence supporting detection of other cardiovascular diseases, including medical emergencies. There may also be a role for wearable devices in screening young populations for predictors of sudden cardiac death. At present device outputs require clinician interpretation, but in the future patients may present to primary or secondary care with a firm diagnosis of arrhythmia and may already be making wearable device guided behaviour changes.
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Adverse childhood experiences and binge-eating disorder in early adolescents - Journal of Eating DisordersBackground Adverse childhood experiences (ACEs) are common and linked to negative health outcomes. Previous studies have found associations between ACEs and binge-eating disorder (BED), though they have mainly focused on adults and use cross-sectional data. The objective of this study was to examine the associations between ACEs and BED in a large, national cohort of 9–14-year-old early adolescents in the US. Methods We analyzed prospective cohort data from the Adolescent Brain Cognitive Development (ABCD) Study (N = 10,145, 2016–2020). Logistic regression analyses were used to determine the associations between self-reported ACEs and BED based on the Kiddie Schedule for Affective Disorders and Schizophrenia at two-year follow-up, adjusting for sex, race/ethnicity, baseline household income, parental education, site, and baseline binge-eating disorder. Results In the sample, (49% female, 46% racial/ethnic minority), 82.8% of adolescents reported at least one ACE and 1.2% had a diagnosis of BED at two-year follow-up. The mean number of ACEs was higher in those with a diagnosis of BED compared to those without (2.6 ± 0.14 vs 1.7 ± 0.02). The association between number of ACEs and BED in general had a dose–response relationship. One ACE (adjusted odds ratio [aOR] 3.48, 95% confidence interval [CI] 1.11–10.89), two ACEs (aOR 3.88, 95% CI 1.28–11.74), and three or more ACEs (aOR 8.94, 95% CI 3.01–26.54) were all associated with higher odds of BED at two-year follow-up. When stratified by types of ACEs, history of household mental illness (aOR 2.18, 95% 1.31–3.63), household violence (aOR 2.43, 95% CI 1.42–4.15), and criminal household member (aOR 2.14, 95% CI 1.23–3.73) were most associated with BED at two-year follow-up. Conclusions Children and adolescents who have experienced ACEs, particularly household challenges, have higher odds of developing BED. Clinicians may consider screening for ACEs and providing trauma-focused care when evaluating patients for BED.
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Newcastle United is part of the Saudi Arabia 2030 visionA country with a questionable background has to be allowed to start somewhere - Newcastle United is part of the Saudi Arabia 2030 vision
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Study: Most people with long COVID face stigma and discriminationThe majority of people living with long COVID experience some form of stigma directly related to their condition, according to a new study published in the journal PLOS ONE.
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Patients with high-risk melanoma had better quality of life on pembrolizumab than on standard immunotherapy regimensPatients with high-risk stage III-IV melanoma who received pembrolizumab after their surgery reported a better quality of life than patients who received the previous standard-of-care treatment with either ipilimumab or high-dose interferon. These findings were from a large clinical trial led by the SWOG Cancer Research Network and are reported in the journal JAMA Oncology.
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Fungi detected in 35 cancer types, often intracellularIn a recent article published in the journal Cell, researchers found fungal deoxyribonucleic acid (DNA) and cells at low abundances across many human cancers, with cancer type-dependent variations in fungus community composition and fungal-bacteriome interactions.
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