New study finds elevated inflammatory cytokines and lymphocytes linked to rare cases of myocarditis after COVID-19 vaccination SciImmunology Yale inflammatory cytokines lymphocytes myocarditis covid COVID19 SARSCoV2 vaccine vaccination
By Neha MathurMay 10 2023Reviewed by Lily Ramsey, LLM In a recent article published in the Science Immunology Journal, researchers investigated a cohort of patients who developed myocarditis or pericarditis shortly after severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid vaccination.
It is most common among adolescents and young males shortly after receipt of the second dose of mRNA vaccines, BNT162b2 or mRNA-1273. Per a recent estimate, the incidence of myopericarditis increased from zero to 35.9 cases per 100,000 males. Other studies suggested that LNP adjuvants in mRNA vaccines trigger aberrant innate and adaptive immune reactivity. Other studies have implicated inflammatory cytokines, natural killer , and T lymphocytes in such a pathology.
Finally, the team conducted clinical follow-up between two to nine months of COVID-19 vaccination using cardiac magnetic resonance imaging to evaluate the long-term effects of myocarditis, pericarditis, or myopericarditis. Instead, the study analysis uncovered that complete cytokinopathy and activation of cytotoxic lymphocytes with unique transcriptional signatures characterized mRNA-LNP vaccine-induced myopericarditis.
These chemokines play important roles in cytotoxic T-cell and TH1 responses and activating infiltration of cardiac tissue by T-cells.
Ireland Latest News, Ireland Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
An evaluation of the timeliness of COVID-19 surveillance data sources and indicatorsAn evaluation of the timeliness of COVID-19 surveillance data sources and indicators CDCgov covid COVID19 SARSCoV2 surveillance data publichealth US USA pandemic
Read more »
Nirmatrelvir/ritonavir reduces the risk of COVID-19-associated hospitalizationNirmatrelvir/ritonavir reduces the risk of COVID-19-associated hospitalization CIDJournal niramatrelvir ritonavir covid COVID19 SARSCoV2 hospitalization
Read more »
A SARS-CoV-2 Vaccine Designed for Manufacturability Results in Unexpected Potency and Non-Waning Humoral ResponseThe rapid development of several highly efficacious SARS-CoV-2 vaccines was an unprecedented scientific achievement that saved millions of lives. However, now that SARS-CoV-2 is transitioning to the endemic stage, there exists an unmet need for new vaccines that provide durable immunity and protection against variants and can be more easily manufactured and distributed. Here, we describe a novel protein component vaccine candidate, MT-001, based on a fragment of the SARS-CoV-2 spike protein that encompasses the receptor binding domain (RBD). Mice and hamsters immunized with a prime-boost regimen of MT-001 demonstrated extremely high anti-spike IgG titers, and remarkably this humoral response did not appreciably wane for up to 12 months following vaccination. Further, virus neutralization titers, including titers against variants such as Delta and Omicron BA.1, remained high without the requirement for subsequent boosting. MT-001 was designed for manufacturability and ease of distribution, and we demonstrate that these attributes are not inconsistent with a highly immunogenic vaccine that confers durable and broad immunity to SARS-CoV-2 and its emerging variants. These properties suggest MT-001 could be a valuable new addition to the toolbox of SARS-CoV-2 vaccines and other interventions to prevent infection and curtail additional morbidity and mortality from the ongoing worldwide pandemic.
Read more »
The new Public Order Act and what new offences protesters can be arrested for, explainedThe Government claimed the timing of the laws, introduced as part of a new Public Order Act, is coincidental After the coronation luciemheath looks into what offences protesters can now be arrested for ⬇️
Read more »
CDC report provides an overview of provisional mortality in the United States during 2022CDC report provides an overview of provisional mortality in the United States during 2022 CDCgov mortality disease health healthnews
Read more »
Household transmission of endemic human coronaviruses in the USHousehold transmission of endemic human coronaviruses in the US CUDenver JohnsHopkinsSPH Cambridge_Uni human coronavirus humancoronavirus transmission humantransmission household householdtransmission
Read more »