Profound immune escape by SARS-CoV-2 XBB.1 even after 4 vaccine doses SARSCoV2 Vaccine Coronavirus Disease COVID TheLancetInfDis FAU_Germany HannoverMh uniGoettingen
Co-infection with different SARS-CoV-2 lineages can lead to the recombination of the distinct viral genomes and the creation of new and recombinant SARS-CoV-2 lineages. First detected in India in January 2022, the recombinant XBB lineage is spreading rapidly throughout Europe and Asia. The XBB lineage was formed due to the recombination of two SARS-CoV-2 Omicron variant sublineages, namely BM.1.1.1 and BJ.1.
About the study In the present study, researchers reported the efficiency with which the SARS-CoV-2 XBB.1 lineage can enter the host cell and evade antibody-mediated neutralization. The team also analyzed the sensitivity of XBB.1pp to neutralization by COVID-19 vaccination or vaccination along with breakthrough infection. Furthermore, plasma samples from triple-vaccinated persons having breakthrough COVID-19 infections during BA.5 prevalence in Germany were assessed.
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