New research finds mechanism that regulates PTSD in the female brain MolPsychiatry
Females are more likely than males to develop post-traumatic stress disorder . However, the neurobiological mechanisms responsible for these sex differences remain elusive. The ubiquitin proteasome system is involved in fear memory formation and implicated in PTSD development. Despite this, proteasome-independent functions of the UPS have rarely been studied in the brain.
-dCas13b-mediated knockdown of K63-polyubiquitination in the amygdala via editing of the K63 codon in the major ubiquitin gene,, impaired fear memory in females, but not males, and caused a reduction in learning-related increases in ATP levels and proteasome activity in the female amygdala.
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