Researchers gain structural insights into the immune modulator Siglec-15 and its interaction with T cells NatureComms
Despite the growing interest in Siglec-15, the development of effective drugs has been hampered by a limited understanding of its structural characteristics and the mechanisms by which it interacts with other molecules. In order to fully exploit the therapeutic potential of Siglec-15, a comprehensive understanding of its structure and molecular interactions is crucial.
A multidisciplinary research team from CIC bioGUNE, led by Jesús Jiménez Barbero, Asís Palazón and June Ereño, through a combination X-ray crystallography, spectroscopy and computational modeling elucidated the crystal structure of Siglec-15 and its binding epitope by co-crystallizing it with an anti-Siglec-15 blocking antibody. The research was first published online in the journal
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