Researchers share results of MVA-BN-respiratory syncytial virus vaccine human challenge trial medrxivpreprint BavarianNordic RSV Vaccine Trial
By Pooja Toshniwal PahariaDec 7 2022Reviewed by Aimee Molineux In a recent study posted to the medRxiv* preprint server, researchers reported the immunogenicity, efficacy, and safety of the MVA-BN -RSV vaccine against RSV-A Memphis 37b strain in a human challenge trial.
The clinical trial was a double-blinded, phase 2a, placebo-controlled randomized clinical trial comprising healthy participants aged from 18 years to 50 years with expected RSV susceptibility [on the basis of neutralizing antibody titers] during screening. Participants were randomly allocated into two groups in a 1:1 ratio to receive either intramuscular MVA-BN-RSV vaccinations or equal volumes of placebo Tris-buffered saline vaccines.
Plaque assays were performed to assess RSV replication. Participant sera were analyzed using ELISA to measure anti-RSV immunoglobulin G and IgA titers and by PRNT to measure nAb titers against RSV-A, B. Further, ELISpot assays were performed for IFN-γ -and IL-4 PMBC enumeration as a response to RSV proteins.
Viral load from nasal wash samples was significantly lower among MVA-BN-RSV vaccinees than placebo vaccinees. Likewise, symptom scores were also lower post-MVA-BN-RSV vaccination. Serological anti-RSV IgA and IgG titers and nAb titers increased by four-fold and two-fold post-MVA-BN-RSV vaccinations, respectively, and robust cellular responses were observed, particularly against the internal RSV proteins.
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