Risk factors for Omicron reinfections among previously infected frontline workers in the United States CDCgov Omicron Reinfection SARSCoV2 COVID19 FrontlineWorker USA
By Neha MathurFeb 1 2023Reviewed by Aimee Molineux In a recent article published in Emerging Infectious Diseases, researchers examined a prospective cohort of frontline workers in the United States previously infected with severe acute respiratory syndrome coronavirus 2 . They attempted to identify risk factors that made this highly vulnerable population prone to reinfection by SARS-CoV-2 new variant of concern , Omicron, known for its high immune evading potential.
Finally, the researchers included those participants who previously had coronavirus disease 2019 a minimum of 45 days before Omicron predominance or who enrolled in this study from US sites where Omicron was predominant. They also collected data on their demographic and preexisting health at enrollment. Likewise, they noted each participant's time-varying vaccination status, self-reported mask use, and time since the previous infection.
Based on the Omicron predominance period, 1,530 participants with prior COVID-19 added 124,665 person-days at reinfection risk. Among mRNA vaccine recipients, 71.2% and 28.8% had received BNT162b2 and mRNA-1273 COVID-19 vaccines, respectively. Within a year of its predominance, Omicron caused the first infections in around 51% of the participants in that area. Likewise, it caused reinfections in 20.8% of the participants, of which 27% remained asymptomatic.
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