Patients can wait a long time for potentially life-saving lung transplants, since the need to find close matches complicates the process. One of the characteristics that need to be matched is patient and donor blood type.
Now new research shows that the blood type of some donated lungs could be altered before transplant, which means there is a bigger pool of universal donor lungs and less time on the waiting list for those in need.
"Because of this, patients with progressively failing organs often wait years for a life-saving transplant, and some will die, never receiving an optimally matched organ. In 2017, less than one-third of patients on the lung transplant waiting list received an organ in the United States." The team estimates that the procedure could eventually increase the number of blood group O donor lungs from the current 55 percent to more than 80 percent in the future."The treatment of donor lungs minimized antibody binding, complement deposition, and antibody-mediated injury as compared with control lungs,"."This strategy has the potential to expand ABO-incompatible lung transplantation and lead to improvements in fairness of organ allocation.
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