A team of researchers has created a bacteria that can produce a steady and consistent source of medicine inside a patient’s gut, suggesting the possibility for genetically edited bacteria. Find out more at 🚀 Engineering
that can produce a steady and consistent source of medicine inside a patient’s gut, suggesting the possibility for genetically edited bacteria to be an efficient Parkinson’s disease treatment.
The study's authors revealed an incremental step forward in designing a novel strain of the human probiotic E.coli Nissle 1917 that has been created to continuously generate L-DOPA, which is a Parkinson’s disease drug that acts as a precursor to dopamine. In the new study aimed to solve this issue, the researchers investigated whether bacteria producing L-DOPA in the gut could result in consistent delivery of the medicine to the brain, and successful in getting the altered bacteria to"eat up" a chemical called tyrosine and spit out L-DOPA.
, professor and Johnny Isakson Chair, Georgia Research Alliance Eminent Scholar at the University of Georgia in Athens, Ga."This next-generation microbial bioengineering technology is designed so that Parkinson’s patients could make their own L-DOPA with microbes in their gut."The researchers also demonstrated that using the modified bacteria resulted in stable blood levels of L-DOPA, which improved motor and cognitive abilities in mice.
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