Scientists explore ex utero generation of post-gastrulation synthetic embryos WeizmannScience ExUtero SyntheticEmbryo Embryo
By Shanet Susan AlexAug 9 2022Reviewed by Aimee Molineux In a recent study published in the Cell journal, researchers showed that post-gastrulation synthetic embryos could be synthesized outside the uterus using mouse naïve embryonic stem cells .
The present study's authors recently developed dynamic and static culture platforms and growth environments enabling continuous recording of natural mouse embryogenesis. It captured embryogenesis from pre-gastrulation to late organogenesis phases outside the uterus. Additionally, the scientists established the ideal growth circumstances for post-implantation mouse embryos, known as Ex Utero Culture Media .
The authors analyzed whether sEmbryos replicate the morphological alterations occurring throughout natural embryo growth. They assessed advanced sEmbryos for appropriate spatial and temporal expression of lineage markers. Further, the team explored whether advanced sEmbryos can promote self-organization using embryo-derived TSC lines . They aimed to well-characterize the formation of extra-embryonic compartments across post-gastrulation sEmbryos.
The aggregated naïve pluripotent stem cells cluster during lineage priming to form egg-cylinder-shaped and fully developed embryo-like models. These embryo-like structures accomplished gastrulation and continued significantly farther to establish neural folds, the brain, gut tube, neural tube, somite, beating heart, and progenitors of other organs.
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