A small clinical trial with 12 rectal cancer patients found remission in 100% of them, according to a new paper published in The New England Journal of Medicine.
“I believe this is the first time this has happened in the history of cancer,” Luis Diaz Jr., MD, the senior study author and an oncologist at Memorial Sloan Kettering Cancer Center in New York City,The study, which was sponsored by the drug company GlaxoSmithKline, was presented Sunday at the annual meeting of the American Society of Clinical Oncology.
Typically, about 1 in 5 patients have a bad reaction to drugs like dostarlimab, which is a checkpoint inhibitor, according to the, allowing it to identify and destroy the cells. Severe complications can include muscle weakness and a hard time swallowing. Cancer researchers agreed that the results will need to be repeated in larger studies, mainly because the small study focused on patients who had a rare genetic signature in their tumors, known as mismatch repair deficiency.
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