Study evaluates the effects of phenolic compounds in extra virgin olive oil on skin health Nutrients_MDPI CanalUGR olive oil oliveoil extravirginoliveoil penolic compounds skin skinhealth health research
By Tarun Sai LomteApr 27 2023Reviewed by Lily Ramsey, LLM A recent study published in the Nutrients Journal evaluated the effects of phenolic compounds in extra virgin olive oil on the proliferation, cell cycle, migration, and antigenic profile of human fibroblasts.
EVOO primarily consists of triacylglycerols, fatty acids, and mono and diacylglycerols. Over 230 minor compounds in EVOO represent 2% of its weight. Fibroblasts were seeded in an estrogen-free medium and cultured for 24 hours under standard conditions. The medium was replaced with another containing one of the phenolic compounds at varying doses.
Findings Fibroblasts treated with tyr or htyr at concentrations of 10-5 M and 10-6 M and with ole at 10-6 M, 10-7 M, and 10-8 M showed significantly increased growth capacity, respectively, compared to untreated controls. Further, malignant transformation or DNA aneuploidy was not observed. Fibroblast treatment with phenolic compounds significantly increased α-actin and fibronectin expression compared to untreated controls at all tested concentrations, except for treatment with tyr at 10-5 M, which yielded no significant changes relative to controls.
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