A Review published in the Annals of General Psychiatry finds that Chinese patients with bipolar disorder have elevated uric acid levels, especially the manic episode in bipolar disorder. However, further studies are needed to verify this association.
] suggest that serum UA levels demonstrated a very good‐to‐excellent prognostic accuracy as a biomarker for conversion to BD in depressed subjects, so it is crucial to explore the association between uric acid levels and bipolar disorder.
This study intends to conduct a meta-analysis of serum uric acid levels in bipolar disorder, depression, schizophrenia, and healthy people, comparing the differences in uric acid levels among different subtypes of bipolar disorder, to provide reference and evidence-based medical support for clinical diagnosis and treatment.Electronic databases, including PubMed, Embase, Web of Science, and China National Knowledge Infrastructure , were searched from inception to December 2022.
]. The NOS scale was used to assess the quality of each study. To integrate more complete and accurate data, one investigator contacted the corresponding authors of studies that did not have explicit data or other unpublished studies.Statistical analyses were conducted by RevMan5.4 and Stata14.2, the standard mean differences of different studies and corresponding 95% confidence intervals were used to estimate the association between the experimental group and control group.
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