TBX20 enhances reprogramming of heart fibroblasts into heart muscle cells CircAHA
One promising strategy to remuscularize the injured heart is the direct cardiac reprogramming of heart fibroblast cells into cardiomyocytes. In a paper published in, University of Alabama at Birmingham researchers Yang Zhou, Ph.D., and Rui Lu, Ph.D., have identified TBX20 as the key missing transcription factor in existing cocktails for direct cardiac reprogramming of human fibroblasts.
An important area for future investigation, Zhou says, will be testing TBX20 in vivo for direct reprogramming. Human heart fibroblasts of the ventricle will be the primary target for evaluation of in vivo reprogramming. Zhou and colleagues showed that TBX20 was essential in reprogramming these fibroblasts to induced-cardiomyocytes, suggesting a therapeutic potential for TBX20.
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