The effect of SGLT2 inhibitors in patients with heart failure and type 2 diabetes UniklinikAachen heartfailure type2diabetes diabetes heartfailure
By Bhavana KunkalikarJun 21 2023Reviewed by Danielle Ellis, B.Sc. In a recent study published in the European Heart Journal, researchers assessed the impact of sodium-dependent glucose co-transporter 2 inhibitors on type 2 diabetes and heart failure patients in real-world clinical settings.
Trials have been conducted on HF patients with preserved ejection fraction or reduced ejection fraction , or those with and without diabetes. SGLT2 inhibitors have since become a crucial aspect of foundational therapy for HF patients, irrespective of their left ventricular ejection fraction. Results The study found that initiating SGLT 2 inhibitors reduced risk with a hazard ratio of 0.72 compared to sitagliptin for the primary composite endpoint. The adjusted relative risk reduction noted for all-cause mortality was 30% with an HR of 0.70, 36% for HFF with an HR of 0.64, and 23% for urgent visits requiring i.v. diuretics with an HR of 0.77.
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