A CBD-inspired salve to chill out irritated complexions
Our editors' clean compendium of the best-in-class products for your faceAssembling your ideal line-up of men's skincare products may seem easy, but it often isn't. As the world of lotions and potions grows ever larger, so too does the potential for a bogus and benign rotation. Nice smells doesn't equate to nasty-free.
A gilded jar doesn't always house the superior formula. And, the sheer volume of stuff can be overwhelming to even the most scientific ofRather than drown in the new wave of lovely men's skincare launches, we want you to surf it. Which is why's style team has tried and tested the great – and the not so great – to keep your bathroom in good nick. If it impressed – as in, really impressed – you'll find it here.
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Neuroimmune proteins can differentiate between tauopathies - Journal of NeuroinflammationBackground Tauopathies are a group of neurodegenerative diseases where there is pathologic accumulation of hyperphosphorylated tau protein (ptau). The most common tauopathy is Alzheimer’s disease (AD), but chronic traumatic encephalopathy (CTE), progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), and argyrophilic grain disease (AGD) are significant health risks as well. Currently, it is unclear what specific molecular factors might drive each distinct disease and represent therapeutic targets. Additionally, there is a lack of biomarkers that can differentiate each disease in life. Recent work has suggested that neuroinflammatory changes might be specific among distinct diseases and offers a novel resource for mechanistic targets and biomarker candidates. Methods To better examine each tauopathy, a 71 immune-related protein multiplex ELISA panel was utilized to analyze anterior cingulate grey matter from 127 individuals neuropathologically diagnosed with AD, CTE, PSP, CBD, and AGD. A partial least square regression analysis was carried out to perform unbiased clustering and identify proteins that are distinctly correlated with each tauopathy correcting for age and gender. Receiver operator characteristic and binary logistic regression analyses were then used to examine the ability of each candidate protein to distinguish diseases. Validation in postmortem cerebrospinal fluid (CSF) from 15 AD and 14 CTE cases was performed to determine if candidate proteins could act as possible novel biomarkers. Results Five clusters of immune proteins were identified and compared to each tauopathy to determine if clusters were specific to distinct disease. Each cluster was found to correlate with either CTE, AD, PSP, CBD, or AGD. When examining which proteins were the strongest driver of each cluster, it was observed the most distinctive protein for CTE was CCL21, AD was FLT3L, and PSP was IL13. Individual proteins that were specific to CBD and AGD were not observ
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The lash serum that Meghan Markle swears by for naturally long lashes is on sale with 25% offIf it's good enough for MeghanMarkle, it's good enough for us.
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This half-price Hotel Chocolat Velvetiser deal is positively mouthwateringGrab the Hotel Chocolat Velvetiser with 50% off - its lowest-ever price
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The best budget cooling mattress is even cheaper with this Black Friday dealGet 35% off the Cocoon by Sealy Chill Memory Foam mattress... plus an extra 25% discount
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You could claim FREE staycation in cabin this winter - check if you qualifyA THOUSAND Brits can claim a free staycation in a luxury cabin this winter A new not-for-profit initiative allows UK carers to chill out on a complimentary three-night getaway as a way of saying a …
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This heated airer is back in stock for Black Friday - and we're buying itIt'll save you money when you dry your clothes
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