Type 2 diabetes takes a toll on the brain altering microstructure Type2Diabetes BrainTissueDamage Mood Cognition ChronicTissueChanges Microstructural BrainChanges FunctionalDeficits SciReports
By Neha MathurJun 18 2023Reviewed by Benedette Cuffari, M.Sc. In a recent study published in the journal Scientific Reports, researchers examine microstructural brain tissue changes in patients with type 2 diabetes using whole-brain diffusion tensor imaging -based mean diffusivity procedures that distinguish acute from chronic stages of tissue change.
To date, researchers have not examined direct correlations between tissue changes in brain sites mediating cognition and mood based on MD. Likewise, symptom scores for mood and cognition in T2D patients have not been reported. DTI data were collected using a single-shot echo planar imaging technique, generalized auto-calibrating partially parallel acquisition , with an acceleration factor of two. Next, a visual assessment of all subjects' T1-, T2-, and PD-weighted images were performed for various pathologies, including cystic lesions, infarcts, or tumors.
Altered brain structure in diabetics Widespread microstructural disruptions were observed in brain regions controlling cognitive and mood functions in people with T2D as compared to controls. Most of these changes were in the chronic stages, with only a few sites in the acute stage. Patients with T2D also exhibited impairments in visuospatial, language, and attention cognitive sub-domains, as well as greater depression and anxiety scores as compared to healthy controls.
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