This article delves into the advanced realm of Magnetic Separation Technology, shedding light on its pivotal role in both biomedical research and industrial applications.
Sponsored Content by SepmagMay 9 2024Reviewed by Maria Osipova Magnetic separation has become increasingly popular in biomedical science and industry. This technology uses magnetic properties of micro/nano-sized particles to separate macromolecules of interest, such as nucleic acids, proteins, and peptides, from biological samples or chemical suspensions.
These advancements have created a need for more efficient magnetic separation technologies to satisfy the demands and replace traditional non-magnetic filtration, centrifugation, and separation approaches. Magnetic separation is the most practical approach for recovering small particles with a diameter of 0.05–1 μm, even in the presence of biological debris and other similar-sized materials. In addition, magnetic separation is highly efficient and particularly well-suited for large-scale purifications.
There is a wealth of research in literature on magnetic beads/particles and how their respective characteristics impact the efficiency of the process they are involved in. Despite the importance of the subject, detailed technical literature describing how magnetic force interact with beads is very thin on the ground.
Some magnetic separation devices attempt to circumvent this issue by using two permanent magnets with opposite polarity. Finding a solution with a magnetic force profile that varies with distance, like in classical magnetic separation racks, can be quite challenging. When beads are separated with a simple neodymium-iron-boron magnet, it is not solely due to the strong magnetic force it generates. Rather, it is primarily because of the significant change in the magnetic force and distance. An inhomogeneous magnetic field is needed to produce a magnetic force.Another crucial concept to consider is that the strength of the magnetic force acting on a bead is influenced by both its magnetic moment and the magnetic force profile.
Fortunately, the companies specializing in advanced magnetic beads separation systems have a wealth of experience in the field and can assist you in determining the final value. When devices with different magnetic forces at each point of the working volume are used, it becomes challenging to validate separation processes. Since the magnetic separation conditions vary for each bead, it is hard to parameterize the process and determine the critical values of an effective setup.
The racks are specifically made to accommodate different quantities of micro-tubes or tubes, depending on the sample volume. Test tube magnetic separators are capable of separating magnetic particles from volumes between approximately 5 microliters and 50 milliliters.The MONITOR hardware and software, along with the QUALITANCE system, allow operators to monitor the entire magnetic separation process by recording and tracking various processes.
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