The latest buzzy diabetes drug is drawing attention for its ability to both control blood sugar and cause weight loss. But doctors and patients are anticipating that the most powerful of these drugs is yet to come
. While semaglutide targets one molecule, glucagon-like peptide-1 , involved in insulin secretion, tirzepatide is the first to target two: GLP-1 and glucose-dependent insulinotropic polypeptide ., an international group of researchers, in collaboration with scientists from Eli Lilly and Novo Nordisk , tried to understand how tirzepatide produces its robust effects on blood sugar and weight.
But to their surprise, the team found that tirzepatide in fact triggers a powerful GIP response. “GIP was indispensable,” says Campbell. In fact, in experiments on insulin-producing pancreatic cells donated from eight volunteers, the researchers found that if GIP was blocked in these cells, preventing the drug from binding to GIP receptors, the drug had no effect on stimulating insulin production. When GIP receptors were not blocked, the cells produced insulin.
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