Do glucose-lowering medications have different effects on kidney outcomes? JAMAInternalMed glucose kidney diabetes type2 T2D T1D health
By Dr. Chinta SidharthanMay 26 2023Reviewed by Lily Ramsey, LLM In a recent study published in the JAMA Internal Medicine Journal, researchers evaluated the kidney outcomes in individuals with type 2 diabetes by comparing four classes of medications added to metformin to lower glucose levels.
Several classes of drugs have exhibited kidney benefits not related to the glycemic effects in type 2 diabetes cases recently. The four classes of medications added to metformin and commonly used to lower glucose levels include sitagliptin, which is a DPP-4 inhibitor; liraglutide, GLP-1 receptor agonist; the sulfonylurea glimepiride; and glargine, the basal insulin.
The measured outcomes included body weight, seated blood pressure, and albumin and creatinine assays to determine kidney function. The change in eGFR between year one and the follow-up was one of the primary measured outcomes, as the eGFR slope is a proxy for the progression of kidney disease among populations with low risk.
The cumulative incidence of composite outcomes of kidney disease progression, largely represented by the progression of albuminuria was 11.5% at the end of the five-year follow-up.
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