A comprehensive review of the scientific literature reveals that immunological, metabolic, and depression-related pathways are the most often reported disease mechanisms. Alzheimer's disease affects almost six million adults in the US, and by 2050, that figure is anticipated to double. Alzheimer'
According to scientists, most recognized biological pathways in the brain are affected by Alzheimer’s disease.
The team discovered that despite significant technological advancements, the most frequently associated biological mechanisms, such as those related to the immune system, metabolism, and long-term depression, have not changed significantly in the past 30 years, despite nearly all known pathways having been linked to the disease. The researchers’ work, which was published in“The burden of Alzheimer’s disease is steadily increasing, driving us towards a neurological epidemic,” said Winston A.
They also found that the top-ranked 30 pathways most frequently referred to in literature remained relatively consistent over the last 30 years suggesting that most studies of the disease have focused on a small subset of all the known disease-associated pathways.
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